[Frontiers in Bioscience 10, 1739-1753, May 1, 2005] 1739 ANGIOGENESIS IN RHEUMATOID ARTHRITIS

1. Abstract 2. Introduction 3. The process of angiogenesis and its experimental models 4. Angiogenic mediators in the rheumatoid synovium 4.1. Heparin-binding growth factors 4.2. Other non-heparin binding growth factors 4.3. Cytokines 4.4. Chemokines and chemokine receptors 4.5. Extracellular matrix components and matrix-degrading proteolytic enzymes 4.6. Cellular adhesion molecules 4.7. Other angiogenic mediators 5. Angiogenesis inhibitors in rheumatoid arthritis 5.1. Cytokines and growth factors 5.2. Chemokines and chemokine receptors 5.3. Protease inhibitors 5.4. Heparin-binding factors 5.5. Antirheumatic drugs 5.6. Angiostatic steroids 5.7. Antibiotics 5.8. Other angiostatic agents 6. Regulation of angiogenesis in the rheumatoid synovium 7. Clinical relevance of angiogenesis research in rheumatology 7.1. Importance for diagnosis and prognosis 7.2. Angiogenesis targeting in antirheumatic therapy 8. Summary 9. Acknowledgement 10. References